目录产品 » CD20/MS4A1 [Biotin], His & Avi, Human
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CD20/MS4A1 [Biotin], His & Avi, Human

B-lymphocyte antigen CD20 or CD20 is an activated-glycosylated phosphoprotein expressed on the surface of all B-cells beginning at the pro-B phase (CD45R , CD117) and progressively increasing in concentration until maturity.CD20 is the target of the monoclonal antibodies rituximab, ocrelizumab, obinutuzumab, ofatumumab, ibritumomab tiuxetan, tositumomab, and ublituximab, which are all active agents in the treatment of all B cell lymphomas, leukemias, and B cell-mediated autoimmune diseases.
￥5800
Z04056-100

产品简介
Species Human
Protein Construction
CD20/MS4A1 [Biotin] (Ile141-Ser188)_x000D_
Accession # P11836-1		 His Avi
N-term C-term
Purity > 95% as determined by Bis-Tris PAGE
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Test result was comparable to standard batch.
Expression System E.coli
Theoretical Molecular Weight 16.8 kDa
Apparent Molecular Weight The protein has a predicted MW of 16.8 kDa same as Bis-Tris PAGE result.
Formulation Supplied as 0.22μm filtered solution in 20mM PB, 500mM NaCl, 0.4M Urea, 10% glycerol, 1mM GSH, 0.1mM GSSG (pH 7.0).
Concentration Verified by one or more methods from 0.64mg/ml A280/Bioactivity/BCA/Bradford.
Storage & Stability This product remains stable for 6 months at -80°C or below. Avoid repeated freeze-thaw cycles.
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技术背景
Target Background B-lymphocyte antigen CD20 or CD20 is an activated-glycosylated phosphoprotein expressed on the surface of all B-cells beginning at the pro-B phase (CD45R , CD117) and progressively increasing in concentration until maturity.CD20 is the target of the monoclonal antibodies rituximab, ocrelizumab, obinutuzumab, ofatumumab, ibritumomab tiuxetan, tositumomab, and ublituximab, which are all active agents in the treatment of all B cell lymphomas, leukemias, and B cell-mediated autoimmune diseases.
Synonyms MS4A1;CD20;MS4A-1;B-lymphocyte surface antigen B1;Bp35;Leukocyte surface antigen Leu-16;Membrane-spanning 4-domains subfamily A member 11
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For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.