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DLL4, His, Human

Delta-like protein 4 (DLL4) is a type I membrane protein belonging to the Delta/Serrate/Lag2 (DSL) family of Notch ligands. Activates NOTCH1 and NOTCH4. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Essential for retinal progenitor proliferation. Required for suppressing rod fates in late retinal progenitors as well as for proper generation of other retinal cell types (By similarity). During spinal cord neurogenesis, inhibits V2a interneuron fate.
￥2100 在线订购包邮(港澳台除外)
Z03954-100

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产品简介
Species Human
Protein Construction
DLL4 (Ser27-Pro524)
Accession # Q9NR61 His		 His
N-term C-term
Purity > 95% as determined by Bis-Tris PAGE
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA.Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 55.38 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 56-70 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from a 0.22 μm filtered solution in PBS, 200 mM L-Arginine (pH 7.4).
Reconstitution It is recommended that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute the lyophilized powder in ddH2O more than 100 μg/ml.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.
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图例
DLL4, His, Human

Immobilized DLL4, His, Human at 1 μg/ml (100 μl/well) on the plate. Dose response curve for Anti-DLL4 Antibody, hFc Tag with the EC50 of 1.6 ng/ml determined by ELISA. »

DLL4, His, Human

DLL4, His, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. »

DLL4, His, Human

The purity of DLL4, His, Human is greater than 90% as determined by SEC-HPLC. »

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技术背景
Target Background Delta-like protein 4 (DLL4) is a type I transmembrane protein with a DSL domain and eight tandem EGF repeats. DLL4 functions as a Notch ligand and activates NOTCH1 and NOTCH4 in the Notch signaling pathway. It is involved in vascular development and homeostasis. DLL4 is involved in vascular development and homeostasis. It is highly expressed in some cancers, such as bladder, breast cancers.
Synonyms DLL4; MGC126344; notch ligand DLL4; Delta4; Delta-like 4
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For laboratory research use only. Direct human use, including taking orally and injection and clinical use are forbidden.