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| Z03823-100 | |
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| Species | Human | ||||||
| Protein Construction |
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| Purity |
> 95% as determined by Bis-Tris PAGE > 95% as determined by HPLC |
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| Endotoxin Level | Less than 1EU per μg by the LAL method. | ||||||
| Biological Activity | Immobilized Nectin-4, His & Avi, Human (Cat.No.: Z03823) at 0.5 μg/ml (100μl/Well) can bind Anti-Nectin-4 Antibody. | ||||||
| Expression System | HEK293 | ||||||
| Theoretical Molecular Weight | 37.2 kDa | ||||||
| Apparent Molecular Weight | Due to glycosylation, the protein migrates to 46-48 kDa based on Bis-Tris PAGE result. | ||||||
| Formulation | Lyophilized from a 0.22 μm filtered solution in PBS, pH 7.4. | ||||||
| Reconstitution | Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water. | ||||||
| Storage & Stability | Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles. |
Immobilized Nectin-4, His & Avi, Human, His Tag at 0.5 μg/ml (100 μl/well) on the plate. Dose response curve for Anti-Nectin-4 Antibody, hFc Tag with the EC50 of 2.6 ng/ml determined by ELISA. »
Immobilized Nectin-4, His & Avi, Human, His Tag at 2 μg/ml (100 μl/well) on the plate. Dose response curve for Human Nectin-1, hFc Tag with the EC50 of 0.27 μg/ml determined by ELISA. »
The purity of Nectin-4, His & Avi, Human is greater than 95% as determined by SEC-HPLC. »
Nectin-4, His & Avi, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. »
| Target Background | Nectin-4 is a tumor-associated antigen. It is probably involved in cell adhesion through trans-homophilic and -heterophilic interactions. Nectin-4 is overexpressed in urothelial carcinoma and several other malignancies. It is a promising target for antibody-drug conjugates (ADCs). |
| Synonyms | EDSS1; LNIR; Nectin4; PRR4; NECTIN4; PVRL4 |
For laboratory research use only. Direct human use, including taking orally and injection and clinical use are forbidden.
