Immobilized Human CA125, His & Avi Tag at 5 μg/ml(100 μl/Well). Dose response curve for Human MSLN with the EC50 of 3.78 μg/ml determined by ELISA.
Recombinant MUC16 Protein on SDS-PAGE under reducing conditions. The purity is greater than 95%.
The purity of Recombinant Human Muc16/CA125 Protein is greater than 95% as determined by SEC-HPLC.
CA125/MUC16, His & Avi, Human
MUC16, also known as the CA125 antigen, is a mucin protein that may be found in type I transmembrane or secreted forms that are used monitor the progress of epithelial ovarian cancer therapy. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. Binding to MSLN mediates heterotypic cell adhesion. This may contribute to the metastasis of ovarian cancer to the peritoneum by initiating cell attachment to the mesothelial epithelium via binding to MSLN.
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