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GMFB, Human

Glia maturation factor beta (GMFB) contains an ADF-H domain，which is a member of the actin-binding proteins ADF family, GMF subfamily. It is a nerve growth factor implicated in nervous system development, angiogenesis, and immune function. GMFB causes differentiation of brain cells, stimulation of neural regeneration, and inhibition of proliferation of tumor cells. It is phosphorylated after phorbol ester stimulation and is crucial for the nervous system. GMFB overexpression in astrocytes results in the increase of BDNF production. GMFB expression is increased by exercise, thus BDNF is important for exercise-induction of BDNF.
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Z03576-100

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产品简介
Species Human
Protein Construction
GMFB (Met1-His142)
Accession # P60983		 Poly-His
N-term C-term
Purity ≥ 95% as analyzed by SDS-PAGE
Endotoxin Level < 1 EU/μg of protein by LAL method
Expression System E. coli
Apparent Molecular Weight ~18 kDa, on SDS-PAGE under reducing conditions.
Formulation Lyophilized from a 0.2 μm filtered solution of 20mM Tris-HCl, 200mM NaCl, pH 8.0.
Reconstitution It is recommended that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute the lyophilized powder in distilled water up to 100 μg/ml.
Storage & Stability Upon receiving, this product remains stable for 6 months at -70°C or -20°C. Upon reconstitution, the product should be stable for 1 week at 4-7°C and for 3 months at -20 °C or below. Avoid repeated freeze-thaw cycles.
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GMFB, Human

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GMFB, Human

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技术背景
Target Background Glia maturation factor beta (GMFB) contains an ADF-H domain，which is a member of the actin-binding proteins ADF family, GMF subfamily. It is a nerve growth factor implicated in nervous system development, angiogenesis, and immune function. GMFB causes differentiation of brain cells, stimulation of neural regeneration, and inhibition of proliferation of tumor cells. It is phosphorylated after phorbol ester stimulation and is crucial for the nervous system. GMFB overexpression in astrocytes results in the increase of BDNF production. GMFB expression is increased by exercise, thus BDNF is important for exercise-induction of BDNF.
Synonyms Glia maturation factor beta; GMF-beta
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For laboratory research use only. Direct human use, including taking orally and injection and clinical use are forbidden.