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GDNF, Human

ED50 < 5.0 µg/ml, measured in a proliferation assay using C6 cells.

GDNF, Human

Lane 1: 2 μg of GDNF, Human, non-reducing (NR)
Lane 2: 2 μg of GDNF, Human, reducing (R)
> 95% as analyzed by SDS-PAGE

GDNF, Human

Glial cell line-derived neurotrophic factor (GDNF) is a neurotrophic factor belonging to the TGF-beta super family and is necessary for neuron survival and phenotypic maintenance in the central and peripheral nervous systems. G-DNF has the potential to support the differentiation and survival of many neuron subpopulations, especially dopaminergic neurons and motor neurons, as well as Purkinje cells and sympathetic neurons. Sertoli cells, type 1 astrocytes, Schwann cells, neurons, pinealocytes and skeletal muscle cells are known to express GDNF in human. GDNF has been shown to interact with GFRA2 and GDNF family receptor alpha 1. Mutations in this gene may be associated with Hirschsprung's disease, Parkinson's disease and amyotrophic lateral sclerosis (ALS).The recombinant human G-DNF expressed in E.coli is a disulfide-linked homo-dimer, with an apparent molecular weight of 17 kDa.
Z03387
￥600

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产品简介
Species Human
Protein Construction

Expressed with an N-terminal Met.

GDNF (Ser78-Ile211)
Accession # P39905
Purity > 95% as analyzed by SDS-PAGE
Endotoxin Level < 0.2 EU/μg of protein by gel clotting method
Biological Activity ED50 < 5.0 µg/ml, measured in a proliferation assay using C6 cells.
Expression System E. coli
Apparent Molecular Weight ~17 kDa, on SDS-PAGE under reducing conditions.
Formulation Lyophilized after extensive dialysis against PBS.
Reconstitution It is recommended that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute the lyophilized powder in ddH₂O or PBS up to 100 μg/ml.
Storage & Stability Upon receiving, this product remains stable for up to 6 months at lower than -70°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. For long term storage it is recommended that a carrier protein (example 0.1% BSA) be added. Avoid repeated freeze-thaw cycles.

图例
  • GDNF, Human
    • GDNF, Human

    ED50 < 5.0 µg/ml, measured in a proliferation assay using C6 cells.

  • GDNF, Human
    • GDNF, Human

    Lane 1: 2 μg of GDNF, Human, non-reducing (NR)
    Lane 2: 2 μg of GDNF, Human, reducing (R)
    > 95% as analyzed by SDS-PAGE


技术背景
Target Background Glial cell line-derived neurotrophic factor (GDNF) is a neurotrophic factor belonging to the TGF-beta super family and is necessary for neuron survival and phenotypic maintenance in the central and peripheral nervous systems. G-DNF has the potential to support the differentiation and survival of many neuron subpopulations, especially dopaminergic neurons and motor neurons, as well as Purkinje cells and sympathetic neurons. Sertoli cells, type 1 astrocytes, Schwann cells, neurons, pinealocytes and skeletal muscle cells are known to express GDNF in human. GDNF has been shown to interact with GFRA2 and GDNF family receptor alpha 1. Mutations in this gene may be associated with Hirschsprung's disease, Parkinson's disease and amyotrophic lateral sclerosis (ALS).The recombinant human G-DNF expressed in E.coli is a disulfide-linked homo-dimer, with an apparent molecular weight of 17 kDa.
Synonyms Glial-Derived Neurotrophic Facto; ATF-1; ATF2; HFB1-GDNF; HSCR3

For laboratory research use only. Direct human use, including taking orally and injection and clinical use are forbidden.


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