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IL-4, Mouse

ED50 < 2.0 ng/ml, measured in a cell proliferation assay using murine HT-2 cells, corresponding to a specific activity of > 5.0 × 105 units/mg.

IL-4, Mouse

Lane 1: 2 μg of IL-4, Mouse, non-reducing (NR)
Lane 2: 2 μg of IL-4, Mouse, reducing (R)
> 95% as analyzed by SDS-PAGE

IL-4, Mouse

Interleukin-4 (IL-4) is a pleiotropic cytokine regulates diverse T and B cell responses including cell proliferation, survival, and gene expression. It has important effects on the growth and differentiation of different immunologically competent cells. Interleukin-4 is produced by mast cells, T cells, and bone marrow stromal cells. IL-4 regulates the differentiation of native CD4+ T cells (Th0 cells) into helper Th2 cells, and regulates the immunoglobulin class switching to the IgG1 and IgE isotypes. IL-4 has numerous important biological functions including stimulating B-cells activation, T-cell proliferation and CD4+ T-cells differentiation to Th2 cells. It is a key regulator in hormone control and adaptive immunity. IL-4 also plays a major role in inflammation response and wound repair via activation of macrophage into M2 cells. IL-4 is stabilized by three disulphide bonds forming a compact globular protein structure. Four alpha-helix bundle with left-handed twist is dominated half of the protein structure with 2 overhand connections and fall into a 2-stranded anti-parallel beta sheet.
Z02996
¥600

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Species Mouse
Protein Construction
IL-4 (His21-Ser140)
Accession # P07750
Purity > 95% as analyzed by SDS-PAGE
> 95% as analyzed by HPLC
Endotoxin Level < 0.2 EU/μg of protein by gel clotting method
Biological Activity ED50 < 2.0 ng/ml, measured in a cell proliferation assay using murine HT-2 cells, corresponding to a specific activity of > 5.0 × 105 units/mg.
Expression System CHO
Apparent Molecular Weight ~15 kDa, on SDS-PAGE under reducing conditions.
Formulation Lyophilized after extensive dialysis against PBS.
Reconstitution It is recommended that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute the lyophilized powder in ddH₂O or PBS up to 100 μg/ml.
Storage & Stability Upon receiving, this product remains stable for up to 6 months at lower than -70°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. For long term storage it is recommended that a carrier protein (example 0.1% BSA) be added. Avoid repeated freeze-thaw cycles.

  • IL-4, Mouse
  • IL-4, Mouse

    ED50 < 2.0 ng/ml, measured in a cell proliferation assay using murine HT-2 cells, corresponding to a specific activity of > 5.0 × 105 units/mg.

  • IL-4, Mouse
  • IL-4, Mouse

    Lane 1: 2 μg of IL-4, Mouse, non-reducing (NR)
    Lane 2: 2 μg of IL-4, Mouse, reducing (R)
    > 95% as analyzed by SDS-PAGE


Target Background Interleukin-4 (IL-4) is a pleiotropic cytokine regulates diverse T and B cell responses including cell proliferation, survival, and gene expression. It has important effects on the growth and differentiation of different immunologically competent cells. Interleukin-4 is produced by mast cells, T cells, and bone marrow stromal cells. IL-4 regulates the differentiation of native CD4+ T cells (Th0 cells) into helper Th2 cells, and regulates the immunoglobulin class switching to the IgG1 and IgE isotypes. IL-4 has numerous important biological functions including stimulating B-cells activation, T-cell proliferation and CD4+ T-cells differentiation to Th2 cells. It is a key regulator in hormone control and adaptive immunity. IL-4 also plays a major role in inflammation response and wound repair via activation of macrophage into M2 cells. IL-4 is stabilized by three disulphide bonds forming a compact globular protein structure. Four alpha-helix bundle with left-handed twist is dominated half of the protein structure with 2 overhand connections and fall into a 2-stranded anti-parallel beta sheet.
Synonyms IL4; B cell growth factor-1; BCGF-1; B cell stimulatory factor-1; BSF-1; B cell differentiation factor; BCDF; T cell growth factor-2; TCGF-2; Mast-cell growth factor-2; MCGF-2

For laboratory research use only. Direct human use, including taking orally and injection and clinical use are forbidden.


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