| ￥840 | |
| RP-D00004-20 | |
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Low-fidelity DNA polymerase with a helicase activity that promotes microhomology-mediated end-joining (MMEJ), an alternative non-homologous end-joining (NHEJ) machinery required to repair double-strand breaks in DNA during mitosis. POLQ is often overexpressed in various cancers, especially those with HR deficiencies, such as BRCA1/2-mutated cancers. |
| Synonyms | POLH |
| Species | Homo sapiens |
| Construct | Helicase domain, aa 1-894 |
| 外观 | Clear liquid |
| Accession# | O75417 |
| Purity | ≥ 90% by SDS-PAGE |
| Endotoxin Level | ≤ 100 EU/mg |
| Source | Insect cell Sf9 |
| Theoretical Molecular Weight | 99 kDa |
| Tag | His tag at the N-terminus |
| Application | Drug discovery for cancer therapeutics. In vitro affinity assays, activity assays etc. |
| Formulation | Supplied as a solution of 50 mM Tris, 500 mM NaCl, 5% Glycerol, 2 mM TCEP, pH 8.0 |
| Storage & Stability | This product remains stable for up to 12 months at -80±5°C. Avoid repeated freeze-thaw cycles. |
| Note | For laboratory research use only. Direct human use, including taking orally and injection and clinical use are forbidden. |
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