| ￥1050 | |
| RP-D00002-20 | |
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The DDB1-DCAF12 complex is part of the CUL4-RBX1-DDB1-DCAF12 (CRL4DCAF12) E3 ubiquitin ligase complex of the DesCEND (destruction via C-end degrons) pathway. DCAF12 is the substrate recognition component of the complex, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation. |
| Species | Homo sapiens |
| Construct | Full length |
| 外观 | Clear liquid |
| Accession# | Q16531, Q5T6F0 |
| Purity | ≥ 90% by SDS-PAGE |
| Endotoxin Level | ≤ 100 EU/mg |
| Source | Insect cell Sf9 |
| Theoretical Molecular Weight | 127 kDa for DDB1, and 52 kDa for DCAF12 |
| Tag | His tag at N-terminus of DCAF12 |
| Application | Drug discovery of Targeted Protein Degradation (TPD) molecules, such as PROTACs and Molecular Glues. In vitro binding assay etc. |
| Formulation | Supplied as a solution of 50 mM Tris， 300 mM NaCl，10% Glycerol， 2 mM TCEP， pH 7.5 |
| Storage & Stability | This product remains stable for up to 12 months at -80±5°C. Avoid repeated freeze-thaw cycles. |
| Note | For laboratory research use only. Direct human use, including taking orally and injection and clinical use are forbidden. |
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