| ￥1050 | |
| RP-D00001-20 | |
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The DDB1-CRBN complex is a crucial component of the E3 ubiquitin ligase system, specifically known as the DCX (DDB1-CUL4-X-box) E3 ubiquitin ligase complex, in which CRBN is the substrate recognition component. The complex tags specific proteins with ubiquitin molecules, signaling them for degradation. This process is essential for maintaining protein homeostasis within the cell. |
| Species | Homo sapiens |
| Construct | Full length |
| 外观 | Clear liquid |
| Accession# | Q16531, Q96SW2 |
| Purity | ≥ 90% by SDS-PAGE |
| Endotoxin Level | ≤ 100 EU/mg |
| Source | Insect cell Sf9 |
| Theoretical Molecular Weight | 127 kDa for DDB1, and 52 kDa for CRBN |
| Tag | His tag at N-terminus of CRBN |
| Application | Drug discovery of Targeted Protein Degradation (TPD) molecules, such as PROTACs and Molecular Glues. In vitro binding assay etc. |
| Formulation | Supplied as a solution of 50 mM Tris, 500 mM NaCl, 10% Glycerol, 2 mM TCEP, pH 7.5 |
| Storage & Stability | This product remains stable for up to 12 months at -80±5°C. Avoid repeated freeze-thaw cycles. |
| Note | For laboratory research use only. Direct human use, including taking orally and injection and clinical use are forbidden. |
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