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| RP30893-1 | |
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A peptide that suppresses neuronal cell death induced by the three different types (mutant amyloid precursor protein, presenilin 1, and presenilin 2) of familial Alzheimer’s Disease genes and by Aß. |
| Synonyms | Humanin, HN |
| Description | Humanin is a variable length peptide that has neuroprotective, cytoprotective, and anti-apoptotic effects. Mitochondrial derived forms are 21 amino acids, while cytosolic forms are 24 amino acids. Humanin may be useful in protecting against Alzheimer's disease, Huntington's disease, prion disease, stroke, oxidative stress, atherosclerosis, type I diabetes, and heart attack. Acts as an agonist for FPR2 and FPR3. |
| Sequence |
{Met}{Ala}{Pro}{Arg}{Gly}{Phe}{Ser}{Cys}{Leu}{Leu}{Leu}{Leu} {Thr}{Ser}{Glu}{Ile}{Asp}{Leu}{Pro}{Val}{Lys}{Arg}{Arg}{Ala} |
| Sequence Shortening | MAPRGFSCLLLLTSEIDLPVKRRA |
| Molecular Formula | C₁₁₉H₂₀₄N₃₄O₃₂S₂ |
| Molecular Weight | 2687.27 |
| Length | 24 |
| Purity | >95% |
| Solubility | Can be dissolved in DMSO |
| Form | Lyophilized |
| Storage | Store at -20°C. Keep tightly closed. Store in a cool dry place. |
