IRL-1620

该产品已下架。

IRL-1620 significantly enhanced delivery and effectiveness of paclitaxel in an animal model of breast cancer. IRL-1620 together with IRL-1038 (Prod. No. ALX-155-007) is an indispensable pharmacological tool to assess the participation of the ETB receptor in some pathophysiological phenomena, by selectively stimulating ETB receptor-mediated responses in various pathophysiological models established in vitro and in vivo.

产品编号	RP13497
规格	定制报价

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Synonyms

IRL-1620; IRL1620

Note

This peptide is most potent and specific ligand for the ETB receptor (KiETA/KiETB=120 000) as judged by the Ki values for ETA (1.9 µM) and ETB (16 pM) receptors. IRL1620 (10-9-10-7 µM) induced contraction of the guinea pig tracheal with a comparable potency to those of ET-1 or ET-3.

产品概述

Cas No	142569-99-1
Sequence	Suc-[Glu9Ala11,15]-Endothelin-1(8-21)Suc-Asp-Glu-Glu-Ala-Val -Tyr-Phe-Ala-His-Leu-Asp-Ile-Ile-Trp
Sequence Shortening	Suc-[Glu9Ala11,15]-Endothelin-1(8-21)Suc-DEEAVYFAHLDIIW
Molecular Formula	C₈₆H₁₁₇N₁₇O₂₇
Molecular Weight	1820.95