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β-Amyloid (25-35)

Beta-amyloid protein (Abeta), a major component of senile plaques of Alzheimer's disease (AD) in the brain, causes elevation of the intracellular free Ca2+ level and the production of robust free radicals. Beta-amyloid 25-35 induced apoptosis, characterized by decreased cell viability, neuronal DNA condensation, and fragmentation, is associated with an increase in intracellular free Ca2+ level, the accumulation of reactive oxygen species (ROS), and the activation of caspase-3. All of these effects induced by beta-amyloid 25-35 are reversed by genistein.
¥500
RP10008

Synonyms βAmyloid; b-Amyloid; bAmyloid; beta-Amyloid; betaAmyloid
Description Beta-amyloid protein (Abeta), a major component of senile plaques of Alzheimer's disease (AD) in the brain, causes elevation of the intracellular free Ca2+ level and the production of robust free radicals. Beta-amyloid 25-35 induced apoptosis, characterized by decreased cell viability, neuronal DNA condensation, and fragmentation, is associated with an increase in intracellular free Ca2+ level, the accumulation of reactive oxygen species (ROS), and the activation of caspase-3. All of these effects induced by beta-amyloid 25-35 are reversed by genistein.
Cas No 131602-53-4
Sequence
{GLY}{SER}{ASN}{LYS}{GLY}{ALA}{ILE}{ILE}{GLY}{LEU}{MET}
Sequence Shortening GSNKGAIIGLM
Molecular Formula C45H81N13O14S1
Molecular Weight 1060.27
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Purity > 95%
Solubility Soluble in dimethyl sulfoxide(Analytical grade) under 1mg/ml
Form Lyophilized
Storage Store the peptide at -20°C
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