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PE7

PE7 is a fusion protein of the small RNA-binding protein La to the prime editor. Research indicates that PE7 has demonstrated substantial improvements in intended editing efficiencies across various cell lines and genomic loci compared to previous versions like PEmax. This development holds promise for a wide range of applications in both basic research and therapeutic settings.
￥1540 在线订购包邮(港澳台除外)
RC00009-30

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产品概述
Description PE7 is a fusion protein of the small RNA-binding protein La to the prime editor. Research indicates that PE7 has demonstrated substantial improvements in intended editing efficiencies across various cell lines and genomic loci compared to previous versions like PEmax. This development holds promise for a wide range of applications in both basic research and therapeutic settings.
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应用指导
single guide RNA (sgRNA) dependent single-stranded DNA cleavage
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产品属性
Expression System Recombinant Cas9-based fusion with three NLS expressed by E.coli
Species S. pyogenes
PAM NGG
Tag C-His tag
Molecular Weight 268.681 KDa
Storage & Stability PE7 is supplied with storage buffer (50 mM Tris, 300 mM NaCl, 0.1 mM EDTA, 1 mM DTT, 50% Glycerol pH7.5, at 25°C) and recommended to be stored at -80°C.
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质控参数
Purity ≥90% by SDS-PAGE, 94% by SEC-HPLC
Residual DNase Non-specific DNase activity
Endotoxin Level Control <10EU/mg
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图例
PE7

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PE7

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技术背景
References Lance R. Parsons, Britt Adamson, et al. “Improving prime editing with an endogenous small RNA-binding protein”, Nature. 2024 Apr;628(8008):639-647.
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