目录产品 » FGFR substrate 2 Antibody, mAb, Rabbit
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FGFR substrate 2 Antibody, mAb, Rabbit

Adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, in response to ligand-mediated activation of FGFR1. Modulates signaling via SHC1 by competing for a common binding site on NTRK1.
￥1200 在线订购包邮(港澳台除外)
A03736-50

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产品概述
Specificity This product is specific to FGFR substrate 2
Host Species Rabbit
Immunogen A synthesized peptide derived from human FGFR substrate 2
Species Reactivity Human
Conjugate Unconjugated
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应用指导
Working concentrations for specific applications should be determined by the investigators. The appropriate concentrations may be affected by secondary antibody affinity, antigen concentration, the sensitivity of the method of detection, temperature, the length of the incubations, and other factors. The suitability of this antibody for applications other than those listed below has not been determined. The following concentration ranges are recommended starting points for this product.
Application Recommended Usage
Western Blot 1:1000-1:2000
Immunoprecipitation (IP) 1:20-1:50
Flow Cytometry 1:20-1:100
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产品属性
Form Liquid
Storage Buffer Supplied in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
Storage Instructions Store at -20°C. This product is stable for 1 year upon receipt, when handled and stored as instructed.
Purification Affinity-chromatography
Isotype Rabbit IgG
Clonality Monoclonal
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图例
FGFR Substrate 2 Antibody, MAb, Rabbit

Western blot analysis of FRS2 expression in HeLa cell lysate. »

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技术背景
Target Background Adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, in response to ligand-mediated activation of FGFR1. Modulates signaling via SHC1 by competing for a common binding site on NTRK1.
Synonyms FGFR signaling adaptor SNT; FGFR substrate 2; FRS2; FRS2A; FRS2 alpha; SNT; SNT1; Suc 1;
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For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.