| Specificity |
This product is specific to PMAIP1 |
| Host Species |
Rabbit |
| Immunogen |
A synthesized peptide derived from human PMAIP1 |
| Species Reactivity |
Human |
| Conjugate |
Unconjugated |
|
Working concentrations for specific applications should be determined by the investigators. The appropriate concentrations may be affected by secondary antibody affinity, antigen concentration, the sensitivity of the method of detection, temperature, the length of the incubations, and other factors. The suitability of this antibody for applications other than those listed below has not been determined. The following concentration ranges are recommended starting points for this product. |
| Application |
Recommended Usage |
| Western Blot |
1:1000-1:2000 |
|
| Form |
Liquid |
| Storage Buffer |
Supplied in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol. |
| Storage Instructions |
Store at -20°C. This product is stable for 1 year upon receipt, when handled and stored as instructed. |
| Purification |
Affinity-chromatography |
| Isotype |
Rabbit IgG |
| Clonality |
Monoclonal |
| Target Background |
Noxa is a pro-apoptotic Bcl-2 family protein that contains a single Bcl-2 homology (BH3) domain. Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. |
| Synonyms |
APR; ATL-derived; NOXA; Pmaip1; Protein Noxa; |
For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.
