目录产品 » DNMT1 Antibody, mAb, Rabbit
Manual
Manual
COAs

DNMT1 Antibody, mAb, Rabbit

Methylation of DNA at cytosine residues in mammalian cells is a heritable, epigenetic modification that is critical for proper regulation of gene expression, genomic imprinting and development. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2.
￥1200 在线订购包邮(港澳台除外)
A03461-50

咨询产品问题
产品概述
Specificity This product is specific to DNMT1
Host Species Rabbit
Immunogen A synthesized peptide derived from human DNMT1
Species Reactivity Human; Mouse; Rat
Conjugate Unconjugated
返回

应用指导
Working concentrations for specific applications should be determined by the investigators. The appropriate concentrations may be affected by secondary antibody affinity, antigen concentration, the sensitivity of the method of detection, temperature, the length of the incubations, and other factors. The suitability of this antibody for applications other than those listed below has not been determined. The following concentration ranges are recommended starting points for this product.
Application Recommended Usage
Western Blot 1:1000-1:2000
Immunohistochemistry (IHC) 1:100-1:200
Immunocytochemistry/Immunofluorescence (ICC/IF) 1:50-1:200
Immunohistochemistry Frozen (IHF) 1:50-1:200
返回

产品属性
Form Liquid
Storage Buffer Supplied in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
Storage Instructions Store at -20°C. This product is stable for 1 year upon receipt, when handled and stored as instructed.
Purification Affinity-chromatography
Isotype Rabbit IgG
Clonality Monoclonal
返回

图例
DNMT1 Antibody, MAb, Rabbit

Western blot analysis of Dnmt1 expression in (1) HEK293 cell lysate; (2) NIH/3T3 cell lysate. »

<
>

技术背景
Target Background Methylation of DNA at cytosine residues in mammalian cells is a heritable, epigenetic modification that is critical for proper regulation of gene expression, genomic imprinting and development. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2.
Synonyms ADCADN; CXXC finger protein 9; CXXC9; DNA methyltransferase 1; DNA MTase; Dnmt1o; HSN1E; M.HsaI; MCMT; Met1; MommeD2;
返回

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.