目录产品 » p-Mlkl (S345) Antibody, mAb, Rabbit
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p-Mlkl (S345) Antibody, mAb, Rabbit

Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process.Does not have protein kinase activity.Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage.
￥1200 在线订购包邮(港澳台除外)
A02552-50

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产品概述
Specificity This product is specific to p-Mlkl (S345)
Host Species Rabbit
Immunogen A synthesized peptide derived from mouse Mlkl around the phosphorylation site of S345
Species Reactivity Mouse
Conjugate Unconjugated
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应用指导
Working concentrations for specific applications should be determined by the investigators. The appropriate concentrations may be affected by secondary antibody affinity, antigen concentration, the sensitivity of the method of detection, temperature, the length of the incubations, and other factors. The suitability of this antibody for applications other than those listed below has not been determined. The following concentration ranges are recommended starting points for this product.
Application Recommended Usage
Western Blot 1:1000-1:2000
Immunoprecipitation (IP) 1:20-1:50
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产品属性
Form Liquid
Storage Buffer Supplied in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
Storage Instructions Store at -20°C. This product is stable for 1 year upon receipt, when handled and stored as instructed.
Purification Affinity-chromatography
Isotype Rabbit IgG
Clonality Monoclonal
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图例
P-Mlkl (S345) Antibody, MAb, Rabbit

Western blot analysis of Phospho-MLKL (S345) expression in (1) L929 treated with Z-VAD + TNF alpha + SM164 cell lysate; (2) Untreated. »

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技术背景
Target Background Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process.Does not have protein kinase activity.Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage.
Synonyms hMLKL ; Mixed lineage kinase domain like; Mixed lineage kinase domain like protein; Mixed lineage kinase domain like pseudokinase;
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For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.