目录产品 » p-SMAD5 (S463/S465) Antibody, mAb, Rabbit
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p-SMAD5 (S463/S465) Antibody, mAb, Rabbit

Transcriptional regulator that plays a role in various cellular processes including embryonic development, cell differentiation, angiogenesis and tissue homeostasis.Upon BMP ligand binding to their receptors at the cell surface, is phosphorylated by activated type I BMP receptors (BMPRIs) and associates with SMAD4 to form an heteromeric complex which translocates into the nucleus acting as transcription factor.
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A02525-50

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产品概述
Specificity This product is specific to p-SMAD5 (S463/S465)
Host Species Rabbit
Immunogen A synthesized peptide derived from human SMAD5 around the phosphorylation site of S463/S465
Species Reactivity Human; Mouse; Rat
Conjugate Unconjugated
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应用指导
Working concentrations for specific applications should be determined by the investigators. The appropriate concentrations may be affected by secondary antibody affinity, antigen concentration, the sensitivity of the method of detection, temperature, the length of the incubations, and other factors. The suitability of this antibody for applications other than those listed below has not been determined. The following concentration ranges are recommended starting points for this product.
Application Recommended Usage
Western Blot 1:1000-1:2000
Immunohistochemistry (IHC) 1:100-1:200
Immunocytochemistry/Immunofluorescence (ICC/IF) 1:50-1:200
Immunohistochemistry Frozen (IHF) 1:50-1:200
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产品属性
Form Liquid
Storage Buffer Supplied in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
Storage Instructions Store at -20°C. This product is stable for 1 year upon receipt, when handled and stored as instructed.
Purification Affinity-chromatography
Isotype Rabbit IgG
Clonality Monoclonal
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图例
P-SMAD5 (S463/S465) Antibody, MAb, Rabbit

Western blot analysis of Phospho-Smad5 in (1)Mouse brain tissue lysate; (2)Rat brain tissue lysate. »

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技术背景
Target Background Transcriptional regulator that plays a role in various cellular processes including embryonic development, cell differentiation, angiogenesis and tissue homeostasis.Upon BMP ligand binding to their receptors at the cell surface, is phosphorylated by activated type I BMP receptors (BMPRIs) and associates with SMAD4 to form an heteromeric complex which translocates into the nucleus acting as transcription factor.
Synonyms hSmad5; JV5-1 ; MADH5; SMAD5; MusMLP ;SMAD family member 5;
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For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.