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Human MTR Antibody (3H1D9), mAb, Mouse

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MTR encodes the 5-methyltetrahydrofolate-homocysteine methyltransferase, which is also known as cobalamin-dependent methionine synthase, catalyzes the final step in methionine biosynthesis. Mutations in MTR have been identified as the underlying cause of methylcobalamin deficiency complementation group G. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. Among its related pathways are Metabolism and Cytochrome P450-arranged by substrate type. Catalyzing the transfer of a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I) alamin and methionine. Subsequently, remethylating the cofactor using methyltetrahydrofolate. KO Validated GenScript Human MTR Antibody (3H1D9), mAb, Mouse is produced from a hybridoma resulting from the fusion of SP2/0 myeloma and B-lymphocytes obtained from a mouse immunized with recombinant human MTR.
A01877
产品概述
Specificity The product is specific for human MTR. This antibody binds with recombinant MTR protein in ELISA and Endogenous MTR in western blot.
Host Species Mouse
Immunogen Recombinant Human MTR
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产品属性
Concentration 0.5 mg/ml, lyophilized with PBS, pH 7.4, containing 0.02% sodium azide. (It could be customized for bulk order.)
Reconstitution Reconstitute the lyophilized antibody with deionized water (or equivalent) to a final concentration of 0.5 mg/ml.
Purification Protein A affinity column
Clone ID 3H1D9
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技术背景
Target Background MTR encodes the 5-methyltetrahydrofolate-homocysteine methyltransferase, which is also known as cobalamin-dependent methionine synthase, catalyzes the final step in methionine biosynthesis. Mutations in MTR have been identified as the underlying cause of methylcobalamin deficiency complementation group G. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. Among its related pathways are Metabolism and Cytochrome P450-arranged by substrate type. Catalyzing the transfer of a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I) alamin and methionine. Subsequently, remethylating the cofactor using methyltetrahydrofolate.
KO Validated GenScript Human MTR Antibody (3H1D9), mAb, Mouse is produced from a hybridoma resulting from the fusion of SP2/0 myeloma and B-lymphocytes obtained from a mouse immunized with recombinant human MTR.
Synonyms Mouse monoclonal to 5-methyltetrahydrofolate-homocysteine methyltransferase, 5-methyltetrahydrofolate-homocysteine methyltransferase 1, cblG, cobalamin-dependent methionine synthase, FLJ33168, FLJ43216, FLJ45386, Methionine synthase, MS, MTR, Vitamin-B12
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