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Soluble RARRES1 induces podocyte apoptosis to promote glomerular disease progression

J Clin Invest. 2020; 
Anqun Chen, Ye Feng, Han Lai, Wenjun Ju, Zhengzhe Li, Yu Li, Andrew Wang, Quan Hong, Fang Zhong, Chengguo Wei, Jia Fu, Tianjun Guan, Bichen Liu, Matthias Kretzler, Kyung Lee, John Cijiang He
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Catalog Antibody … either GAPDH or β-actin. The following antibodies were used in this study: Human RARRES1 antibody (R&D AF4255), V5 (GenScript, Cat#: A01724), FLAG (Sigma, F3165), human RIOK1 (Abcam, ab176005), Cleaved Caspase-3 (Cell signal # 9664) … Get A Quote

摘要

Using the Nephrotic Syndrome Study Network Consortium data set and other publicly available transcriptomic data sets, we identified retinoic acid receptor responder protein 1 (RARRES1) as a gene whose expression positively correlated with renal function decline in human glomerular disease. The glomerular expression of RARRES1, which is largely restricted to podocytes, increased in focal segmental glomerulosclerosis (FSGS) and diabetic kidney disease (DKD). TNF-α was a potent inducer of RARRES1 expression in cultured podocytes, and transcriptomic analysis showed the enrichment of cell death pathway genes with RARRES1 overexpression. The overexpression of RARRES1 indeed induced podocyte apoptosis in vitro. Notab... More

关键词

Apoptosis, Cell Biology, Chronic kidney disease, Nephrology, Signal transduction