至今,GenScript的服务及产品已被Cell, Nature, Science, PNAS等1300多家生物医药类杂志引用近万次,处于行业领先水平。NIH、哈佛、耶鲁、斯坦福、普林斯顿、杜克大学等约400家全球著名机构使用GenScript的基因合成、多肽服务、抗体服务和蛋白服务等成功地发表科研成果,再次证明GenScript 有能力帮助业内科学家Make research easy.

Chemokine Signatures Of Pathogen-Specific T Cells I: Effector T Cells

biorxiv. 2020; 
Jens Eberlein,  Bennett Davenport,  Tom T. Nguyen,  Francisco Victorino, Kevin Jhun, Verena van der Heide, Maxim V. Kuleshov, Avi Ma’ayan,  Ross Kedl,   Dirk Homann
Products/Services Used Details Operation
Catalog Peptides Peptides corresponding to the indicated pathogens, ovalbumin or I-Ea epitopes were obtained from Peptidogenic, the NJH Molecular Core Facility or GenScript at purities of >95% (GP: glycoprotein; NP or N: nucleoprotein); their MHC-restriction and amino acid sequences are indicated. Get A Quote

摘要

The choreography of complex immune responses, including the priming, differentiation, and modulation of specific effector T cell populations generated in the immediate wake of an acute pathogen challenge, is in part controlled by chemokines, a large family of mostly secreted molecules involved in chemotaxis and other patho/physiological processes. T cells are both responsive to varied chemokine cues and a relevant source for certain chemokines themselves. Yet the actual range, regulation, and role of effector T cell-derived chemokines remains incompletely understood. Here, using different in vivo models of viral and bacterial infection as well as protective vaccination, we have defined the entire spectrum of ch... More

关键词