Products/Services Used | Details | Operation |
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Catalog Peptides> | Peptides corresponding to the indicated pathogens, ovalbumin or I-Ea epitopes were obtained from Peptidogenic, the NJH Molecular Core Facility or GenScript at purities of >95% (GP: glycoprotein; NP or N: nucleoprotein); their MHC-restriction and amino acid sequences are indicated. | Get A Quote |
The choreography of complex immune responses, including the priming, differentiation, and modulation of specific effector T cell populations generated in the immediate wake of an acute pathogen challenge, is in part controlled by chemokines, a large family of mostly secreted molecules involved in chemotaxis and other patho/physiological processes. T cells are both responsive to varied chemokine cues and a relevant source for certain chemokines themselves. Yet the actual range, regulation, and role of effector T cell-derived chemokines remains incompletely understood. Here, using different in vivo models of viral and bacterial infection as well as protective vaccination, we have defined the entire spectrum of ch... More