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Nanofibrous hydrogels with spatially patterned biochemical signals to control cell behavior.

Adv Mater. 2015; 
Wade RJ, Bassin EJ, Gramlich WM, Burdick JA.
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Catalog Peptides … PBS. For cell‐culture studies, 0.5 × 10 –3 m thiolated RGD (sequence: GCGYGRGDSPG, GenScript) was included as a cell adhesive biomolecule and 0.25 × 10 –3 m GCDD‐Rho was included to indicate RGD location. Photomask … Get A Quote

摘要

The ability to spatially pattern biochemical signals into nanofibrous materials using thiol-ene reactions of thiolated molecules to presented norbornene groups is demonstrated. This approach is used to pattern three molecules independently within one scaffold, to pattern molecules through the depth of a scaffold, and to spatially control cell adhesion and morphology.,© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

关键词

alignment; electrospinning; nanofibers; patterning; tissue engineering