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Circulating CASK is associated with recurrent focal segmental glomerulosclerosis after transplantation.

PLoS ONE. 2019;

BeaudreuilSeverine，ZhangXiaomeng，HerrFlorence，HarperFrancis，CandelierJean Jacques，FanYe，YeterHilal，DudreuilhCaroline，LecruLola，VazquezAime，CharpentierBernard，LorenzoHans K，DurrbachAnt

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Custom Vector Construction	… DNA was digested with BamHI and EcoRI and subcloned into a pTrcHis2C vector (Invitrogen) for subsequent expression and purification from Escherichia coli. Expression and purification were performed by GenScript services (Piscataway, NJ, USA) …	Get A Quote

摘要

Focal and Segmental GlomeruloSclerosis (FSGS) can cause nephrotic syndrome with a risk of progression to end-stage renal disease. The idiopathic form has a high rate of recurrence after transplantation， suggesting the presence of a systemic circulating factor that causes glomerular permeability and can be removed by plasmapheresis or protein-A immunoadsorption.