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MicroRNA-34a inhibits human trophoblast cell invasion by targeting MYC.

BMC Cell Biol.. 2015; 
SunManni,ChenHaiying,LiuJing,TongChunxiao,Men
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Custom Vector Construction a non-targeting control (NC) sequence (5′-GATCCCCTTCTCCGAACGTGTCACGTTTCAAGAGAACGTGACACGTTCGGAGAATTTTT-3′, sense strand, with BamHI/HindIII restriction sites) were cloned into the pRNA-H1.1/Neo siRNA expression vector (GenScript, Piscataway, NJ, USA) Get A Quote

摘要

Preeclampsia, one of the major disorders of pregnancy, is characterized by inadequate trophoblast invasion and defective trophoblast-mediated remodeling of placental vasculature. MicroRNA-34a (miR-34a) has been found to be aberrantly expressed in the placentas of preeclamptic patients, yet its role in placental development and in the pathogenesis of preeclampsia remains elusive.

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