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MicroRNA-34a inhibits human trophoblast cell invasion by targeting MYC.

BMC Cell Biol.. 2015;

SunManni，ChenHaiying，LiuJing，TongChunxiao，Men

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摘要

Preeclampsia， one of the major disorders of pregnancy， is characterized by inadequate trophoblast invasion and defective trophoblast-mediated remodeling of placental vasculature. MicroRNA-34a (miR-34a) has been found to be aberrantly expressed in the placentas of preeclamptic patients， yet its role in placental development and in the pathogenesis of preeclampsia remains elusive.