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Glucose-6-phosphate dehydrogenase and NADPH oxidase 4 control STAT3 activity in melanoma cells through a pathway involving reactive oxygen species， c-SRC and SHP2.

Am J Cancer Res. 2015;

CaiTianchi，KuangYingmin，ZhangChunhua，ZhangZheng，ChenLong，LiBo，LiYuqian，WangYanling，YangHuixin，HanQiaoqiao，ZhuYue

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摘要

Glucose-6-phosphate dehydrogenase (G6PD) participates in glucose utilization by catalysing the first step of the pentose-phosphate pathway in mammalian cells. Previous studies have shown that changes in G6PD levels can promote tumor cell proliferation or apoptosis via the STAT3/5 pathway in a human melanoma xenograft model. G6PD cooperates with NADPH oxidase 4 (NOX4) in the cellular metabolism of reactive oxygen species (ROS) and in maintaining the intracellular redox state.