Current seasonal influenza vaccines are believed to confer protection against a narrow range of virus strains. However， their protective ability is commonly estimated based on an in vitro correlate of protection that only considers a subset of anti-influenza antibodies that are typically strain specific， i.e.， hemagglutination inhibiting antibodies. Here， we evaluate the breadth of protection induced with a seasonal trivalent influenza vaccine (composition H1N1 A/California/07/09， H3N2 A/Victoria/210/08， B/Brisbane/60/08) against influenza challenge in mice.
Current seasonal influenza vaccines are believed to confer protection against a narrow range of virus strains. However， their protective ability is commonly estimated based on an in vitro correlate of protection that only considers a subset of anti-influenza antibodies that are typically strain specific， i.e.， hemagglutination inhibiting antibodies. Here， we evaluate the breadth of protection induced with a seasonal trivalent influenza vaccine (composition H1N1 A/California/07/09， H3N2 A/Victoria/210/08， B/Brisbane/60/08) against influenza challenge in mice.
