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Protection against H5N1 by multiple immunizations with seasonal influenza vaccine in mice is correlated with H5 cross-reactive antibodies.

Vaccine. 2015-03; 
RoosAnna,RoozendaalRamon,TheeuwsenJessica,RiahiSarra,VanemanJoost,TolboomJeroen,DekkingLiesbeth,KoudstaalWouter,GoudsmitJaap,RadoševićKata
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Custom Vector Construction … sequences with flanking mir223 sequences into the lentiviral LeGO-V2 vector containing a SFFV-driven Venus reporter [34] The shRNA miR sequences with mir223 loop were synthesized by genscript USA Inc (NJ, USA) and the … Get A Quote

摘要

Current seasonal influenza vaccines are believed to confer protection against a narrow range of virus strains. However, their protective ability is commonly estimated based on an in vitro correlate of protection that only considers a subset of anti-influenza antibodies that are typically strain specific, i.e., hemagglutination inhibiting antibodies. Here, we evaluate the breadth of protection induced with a seasonal trivalent influenza vaccine (composition H1N1 A/California/07/09, H3N2 A/Victoria/210/08, B/Brisbane/60/08) against influenza challenge in mice.

关键词

Correlate of protection.,Heterosubtypic protection,Influenza challenge model,Mice,Seasonal influenza vaccine,Serum tran