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Human TM9SF4 Is a New Gene Down-Regulated by Hypoxia and Involved in Cell Adhesion of Leukemic Cells.

PLoS ONE. 2015; 
PaolilloRosa,SpinelloIsabella,QuarantaMaria Teresa,PasquiniLuca,PelosiElvira,Lo CocoFrancesco,TestaUgo,LabbayeCathe
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Custom Vector Construction … Prom-TM9SF4) Human HIF-1α full length cDNA was cloned into a pcDNA31(+) expression vector (pcDNA31/HIF-1α vector from GenScript, Piscataway, NJ, USA) All vectors were checked by automated sequencing In luciferase … Get A Quote

摘要

The transmembrane 9 superfamily protein member 4, TM9SF4, belongs to the TM9SF family of proteins highly conserved through evolution. TM9SF4 homologs, previously identified in many different species, were mainly involved in cellular adhesion, innate immunity and phagocytosis. In human, the function and biological significance of TM9SF4 are currently under investigation. However, TM9SF4 was found overexpressed in human metastatic melanoma and in a small subset of acute myeloid leukemia (AMLs) and myelodysplastic syndromes, consistent with an oncogenic function of this gene.

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