| Products/Services Used | Details | Operation |
|---|---|---|
| Custom Vector Construction | … Preparation of rSPA antigen A 245 bp fragment of the rSPA gene (verified via the National Center for Biotechnology Information website) was optimized based on E coli codon usage, synthesized by GenScript, and subcloned into the pET-44a expression vector … | Get A Quote |
In our study， transcriptome microarrays are used to identify differentially expressed miRNAs and mRNAs in cervical cancer specimens. We find that microRNA-145 (miR-145) expression is significantly decreased in cervical cancer tissues and cell lines， and is associated with advanced cancer stages， large tumor size and moderate/poor differentiation. We show that miR-145 targets the DNA damage repair-associated gene Helicase-like transcription factor (HLTF)， which is involved in radio-resistance. Moreover， miR-145 over-expression in cervical cancer cells enhances radiosensitivity in vitro and in vivo. These results indicate that targeting miR-145 may be a novel radiosensitizing strategy for cervical cance... More
