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TAOK3 phosphorylates the methylenecyclopropane nucleoside MBX 2168 to its monophosphate.

Antiviral Res.. 2015; 
Komazin-MeredithGloria,CardinaleSteven C,ComeauKatelyn,MagalhaesKevin J,HartlineCaroll B,WilliamsJohn D,OppermanTimothy J,PrichardMark N,BowlinTer
Products/Services Used Details Operation
Custom Vector Construction … (Ness Ziona, Israel) and recombinant human PKN1 and PKN2 serine/threonine protein kinases were purchased from Invitrogen 26 Protein expression and purification Human deoxyguanosine kinase (dGK) in a pUC57 vector was purchased from Genscript Get A Quote

摘要

Monohydroxymethyl methylenecyclopropane nucleosides (MCPNs) with ether or thioether substituents at the 6-position show promise as broad-spectrum herpes virus inhibitors. Their proposed mechanism of action involves sequential phosphorylation to a triphosphate, which can then inhibit viral DNA polymerase. The inhibition of herpes simplex virus (HSV) by these compounds is not dependent on the viral thymidine kinase (TK), which is known to phosphorylate acyclovir (ACV), a standard treatment for HSV infections. Previous studies on the mechanism of action of these compounds against human cytomegalovirus (HCMV) implicated a host kinase in addition to HCMV UL97 kinase in performing the initial phosphorylation. A... More

关键词

Herpes simplex virus,Mechanism of action,Monohydroxymethyl methylenecyclopropane nucleosides,T