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Synthetic Oligodeoxynucleotides Containing Multiple Telemeric TTAGGG Motifs Suppress Inflammasome Activity in Macrophages Subjected to Oxygen and Glucose Deprivation and Reduce Ischemic Brain Injury in Stroke-Prone Spontaneously Hypertensive Rats.

PLoS ONE. 2015; 
ZhaoJing,MouYongshan,BernstockJoshua D,KlimanisDace,WangSixian,SpatzMaria,MaricDragan,JohnsonKory,KlinmanDennis M,LiXiaohong,LiXinhui,HallenbeckJo
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Custom Vector Construction … GGA AAG AGA CUC AUA GAA A; and antisense, UUU CUA UGA CUC UCU UUC C After confirmation of effective knockdown of HIF-1alpha genes by these siRNAs in cultured cells, the sequences were constructed into a pRNA-CMV32 vector (Genscript, Piscataway, NJ) to … Get A Quote

摘要

The immune system plays a fundamental role in both the development and pathobiology of stroke. Inflammasomes are multiprotein complexes that have come to be recognized as critical players in the inflammation that ultimately contributes to stroke severity. Inflammasomes recognize microbial and host-derived danger signals and activate caspase-1, which in turn controls the production of the pro-inflammatory cytokine IL-1β. We have shown that A151, a synthetic oligodeoxynucleotide containing multiple telemeric TTAGGG motifs, reduces IL-1β production by activated bone marrow derived macrophages that have been subjected to oxygen-glucose deprivation and LPS stimulation. Further, we demonstrate that A151 red... More

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