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Pharmacological Effects of EGLP-1, a Novel Analog of Glucagon-Like Peptide-1, on Carbohydrate and Lipid Metabolism.

Cell. Physiol. Biochem.. 2018; 
GaoHuashan,SongZiwei,ZhaoQian,WuYou,TangShanshan,AlahdalMurad,ShenYumeng,XingYun,PanYi,LiJing,ZhangYanfeng,JinL
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Peptide Synthesis … effect on NEFA lipid metabolism. Materials and Methods. Peptide synthesis. GLP-1, exendin-4, and EGLP-1 were chemically synthesized by GenScript (Nanjing, China). Biological activities in vitro. The CG-HEK293 cell line was … Get A Quote

摘要

Abnormal glucose metabolism and lipid metabolism are two key issues in Type 1 diabetes mellitus (T1DM). Insulin can control carbohydrate metabolism adequately, but cannot regulate lipid metabolism well in patients with T1DM. Glucagon-like peptide-1 receptor agonists (GLP-1RAs) have cured type 2 diabetes mellitus in clinical trials and have improved T1DM glycemic control in preclinical studies. However, previous studies have not reported whether GLP-1 can lower the serum concentration of non-esterified fatty acids (NEFAs). In this study, we examine whether GLP-1 can affect serum NEFA levels.

关键词

EGLP-1,NEFA,PHSL,STZ-induced hyperglycemia