目录产品 » RANKL/TNFSF11/CD254, Human
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RANKL/TNFSF11/CD254, Human

Receptor activator of nuclear factor κB (RANK) and its ligand (RANKL) have originally been described for their key roles in bone metabolism and the immune system. Subsequently, it has been shown that the RANKL-RANK system is critical in the formation of mammary epithelia in lactating females and the thermoregulation of the central nervous system. RANKL and RANK are under the tight control of the female sex hormones estradiol and progesterone.
￥4100
Z05784-100

产品简介
Species Human
Protein Construction
RANKL/TNFSF11/CD254 (Gly63-Asp244)_x000D_
Accession # O14788-2
Purity > 95% as determined by Bis­Tris PAGE 
Endotoxin Level Less than 0.1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 20.5 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 30-60 kDa based on Bis-Tris PAGE result.
Formulation Supplied as 0.22 μm filtered solution in PBS (pH 7.4)
Concentration Verified by one or more methods from 0.64mg/ml A280/Bioactivity/BCA/Bradford.
Storage & Stability This product remains stable for 6 months at -80°C or below. Avoid repeated freeze-thaw cycles.
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技术背景
Target Background Receptor activator of nuclear factor κB (RANK) and its ligand (RANKL) have originally been described for their key roles in bone metabolism and the immune system. Subsequently, it has been shown that the RANKL-RANK system is critical in the formation of mammary epithelia in lactating females and the thermoregulation of the central nervous system. RANKL and RANK are under the tight control of the female sex hormones estradiol and progesterone.
Synonyms ODF; OPGL; RANKL; TRANCE; CD254; sOdf; TNFSF11; OPTB2
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For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.