目录产品 » NKp30/NCR3/CD337 hFc Chimera, Human
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NKp30/NCR3/CD337 hFc Chimera, Human

NKp30, along with NKp44 and NKp46, constitute a group of receptors termed "Natural Cytotoxicity Receptors". These receptors play a major role in triggering NK-mediated killing of most tumor cells lines.NKp30 stimulates NK cells cytotoxicity toward neighboring cells producing these ligands. It controls, for instance, NK cells cytotoxicity against tumor cells. Engagement of NCR3 by BAG6 also promotes myeloid dendritic cells (DC) maturation, both through killing DCs that did not acquire a mature phenotype, and inducing the release by NK cells of TNFA and IFNG which promote DC maturation.
￥2600
Z05691-100

产品简介
Species Human
Protein Construction
NKp30/NCR3/CD337 (Leu19-Thr138)
Accession # AAH52582		 hFc
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 39.8 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 53-60 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.
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图例
NKp30/NCR3/CD337 HFc Chimera, Human

Immobilized NKp30/NCR3/CD337 hFc Chimera, Human, hFc Tag at 1 μg /ml (100 μl/well) on the plate. Dose response curve for Biotinylated Anti-NKp30 Antibody, hFc Tag with the EC50 of 2.2ng/ml determined by ELISA. »

NKp30/NCR3/CD337 HFc Chimera, Human

The purity of NKp30/NCR3/CD337 hFc Chimera, Human is greater than 95% as determined by SEC-HPLC. »

NKp30/NCR3/CD337 HFc Chimera, Human

NKp30/NCR3/CD337 hFc Chimera, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. »

NKp30/NCR3/CD337 HFc Chimera, Human

NKp30/NCR3/CD337 hFc Chimera, Human, hFc Tag captured on CM5 Chip via Protein A can bind Human B7-H6, His Tag with an affinity constant of 48.67 nM as determined in SPR assay (Biacore T200). »

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技术背景
Target Background NKp30, along with NKp44 and NKp46, constitute a group of receptors termed 'Natural Cytotoxicity Receptors'. These receptors play a major role in triggering NK-mediated killing of most tumor cells lines.NKp30 stimulates NK cells cytotoxicity toward neighboring cells producing these ligands. It controls, for instance, NK cells cytotoxicity against tumor cells. Engagement of NCR3 by BAG6 also promotes myeloid dendritic cells (DC) maturation, both through killing DCs that did not acquire a mature phenotype, and inducing the release by NK cells of TNFA and IFNG which promote DC maturation.
Synonyms CD337; LY117; NCR3; NKp30; 1C7; MALS
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For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.