| Species |
Human |
| Protein Construction |
Integrin alpha 6 beta 1 (ITGA6&ITGB1) Heterodimer [Phe24-Gly1012 (ITGA6) acidic tail and GIn21-Asp728 (ITGB1) basic tail]
Accession # P23229-2 (ITGA6) & P05556-1 (ITGB1) |
His |
Avi |
| N-term |
|
C-term |
|
| Purity |
> 95% as determined by Bis-Tris PAGE |
| Endotoxin Level |
Less than 1 EU per μg by the LAL method. |
| Expression System |
HEK293 |
| Theoretical Molecular Weight |
117.9 kDa (ITGA6) and 83.2 kDa (ITGB1) |
| Apparent Molecular Weight |
Due to glycosylation, the protein migrates to 140-160 kDa (ITGA6) and 110-150 kDa (ITGB1) under Non reducing (N) condition based on Bis-Tris PAGE result. |
| Formulation |
Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4). |
| Reconstitution |
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water. |
| Storage & Stability |
Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles. |
| Target Background |
Integrin alpha-6/beta-1 (ITGA6:ITGB1) is a receptor for laminin on platelets. Integrin alpha-6/beta-1 (ITGA6:ITGB1) is present in oocytes and is involved in sperm-egg fusion. Integrin alpha-6/beta-4 (ITGA6:ITGB4) is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome (By similarity). ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling |
| Synonyms |
α6β1; Integrin alpha 6 beta 1; ITGA6&ITGB1;Integrin alpha 6 β 1 |
For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.
