目录产品 » IL-31 RA hFc Chimera, Human
Manual
COAs

IL-31 RA hFc Chimera, Human

Interleukin-31 receptor A (IL-31RA) is a newly identified type I cytokine receptor, that is related to gp130, the common receptor of the interleukin (IL) -6 family cytokines. IL-31RA forms a functional receptor complex for IL-31 together with the beta subunit of oncostatin M receptor (OSMRbeta). OSMRbeta is expressed in a subset of small-sized nociceptive neurons of adult dorsal root ganglia (DRGs).IL-31 and OSM may thus have redundant functions in the development of OSMRbeta-expressing neurons.
￥3500
Z05498-100

产品简介
Species Human
Protein Construction
IL-31 RA (Ala20-Glu519)
Accession # Q8NI17-1		 hFc
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 83.8 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 110-135 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.
返回

图例
IL-31 RA HFc Chimera, Human

Immobilized Human IL-31, His Tag at 5 μg/ml (100 μl/well) on the plate. Dose response curve for IL-31 RA hFc Chimera, Human, hFc Tag with the EC50 of 0.82 μg/ml determined by ELISA. »

IL-31 RA HFc Chimera, Human

Immobilized IL-31 RA hFc Chimera, Human at 5 μg/ml(100 μl/well) on the plate. Dose response curve for Biotinylated Anti-IL-31 RA Antibody, hFc Tag with the EC50 of 16.9ng/ml determined by ELISA. »

IL-31 RA HFc Chimera, Human

The purity of IL-31 RA hFc Chimera, Human is greater than 95% as determined by SEC-HPLC. »

IL-31 RA HFc Chimera, Human

IL-31 RA hFc Chimera, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. »

IL-31 RA HFc Chimera, Human

IL-31 RA hFc Chimera, Human, hFc Tag captured on CM5 Chip via Protein A can bind Human IL-31, His Tag with an affinity constant of 1.97 nM as determined in SPR assay (Biacore T200). »

<
>

技术背景
Target Background Interleukin-31 receptor A (IL-31RA) is a newly identified type I cytokine receptor, that is related to gp130, the common receptor of the interleukin (IL) -6 family cytokines. IL-31RA forms a functional receptor complex for IL-31 together with the beta subunit of oncostatin M receptor (OSMRbeta). OSMRbeta is expressed in a subset of small-sized nociceptive neurons of adult dorsal root ganglia (DRGs).IL-31 and OSM may thus have redundant functions in the development of OSMRbeta-expressing neurons.
Synonyms IL-31RA; IL-31R-alpha; Gp130-like receptor; CRL3; GPL; ZcytoR17; GLM-R; CRL3Glmr; GLM-RMGC125346; PRO21384
返回

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.