目录产品 » IL-1F10/IL-38, His, Human
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IL-1F10/IL-38, His, Human

Interleukin (IL)-38, a newly discovered IL-1 family cytokine, is expressed in several tissues and secreted by various cells. IL-38 has recently been reported to exert an anti-inflammatory function by binding to several receptors, including interleukin-36 receptor (IL-36R), interleukin-1 receptor accessory protein-like 1 (IL-1RAPL1), and interleukin-1 receptor 1 (IL-1R1) to block binding with other pro-inflammatory cytokines and inhibit subsequent signaling pathways; thereby regulating the differentiation and function of T cells, peripheral blood mononuclear cells, macrophages, and dendritic cells.
￥2600
Z05458-100

产品简介
Species Human
Protein Construction
IL-1F10/IL-38 (Met1-Trp152)
Accession # AAK68048.1		 His
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE
> 95% as determined by HPLC
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Human IL­1 Rrp­2, hFc Tag captured on CM5 Chip via Protein A can bind IL-1F10/IL-38, His, Human in SPR assay (Biacore T200). Test result was comparable to standard batch.
Expression System Yeast
Theoretical Molecular Weight 18.07 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 20-23 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.
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图例
IL-1F10/IL-38, His, Human

The purity of IL-1F10/IL-38, His, Human is greater than 95% as determined by SEC-HPLC. »

IL-1F10/IL-38, His, Human

IL-1F10/IL-38, His, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. »

IL-1F10/IL-38, His, Human

Human IL-1 Rrp-2, hFc Tag captured on CM5 Chip via Protein A can bind IL-1F10/IL-38, His, Human, His Tag with an affinity constant of 35.38 μM as determined in SPR assay (Biacore T200). »

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技术背景
Target Background Interleukin (IL)-38, a newly discovered IL-1 family cytokine, is expressed in several tissues and secreted by various cells. IL-38 has recently been reported to exert an anti-inflammatory function by binding to several receptors, including interleukin-36 receptor (IL-36R), interleukin-1 receptor accessory protein-like 1 (IL-1RAPL1), and interleukin-1 receptor 1 (IL-1R1) to block binding with other pro-inflammatory cytokines and inhibit subsequent signaling pathways; thereby regulating the differentiation and function of T cells, peripheral blood mononuclear cells, macrophages, and dendritic cells.
Synonyms FIL1 theta; IL-1HY2; IL-1 theta; IL38;
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For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.