目录产品 » Integrin alpha V beta 3 (ITGAV&ITGB3) Heterodimer, His, Cynomolgus
Manual
SDS
COAs

Integrin alpha V beta 3 (ITGAV&ITGB3) Heterodimer, His, Cynomolgus

ITGAV&ITGB3 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling. ITGAV&ITGB3 binds to FGF1 and this binding is essential for FGF1 signaling. ITGAV&ITGB3 binds to FGF2 and this binding is essential for FGF2 signaling. ITGAV&ITGB3 binds to IGF1 and this binding is essential for IGF1 signaling. ITGAV&ITGB3 binds to IGF2 and this binding is essential for IGF2 signaling.
￥4100
Z04850-100

产品简介
Species Cynomolgus
Protein Construction
Integrin alpha V beta 3 (ITGAV & ITGB3) Heterodimer [Phe31-Pro993 (ITGAV) acidic tail & Gly27-Asp718 (ITGB3) basic tail]
Accession # A0A2K5WCD3 (ITGAV) & A0A2K5WYN9 (ITGB3)		 His
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
> 95% as determined by HPLC
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Immobilized Integrin alpha V beta 3 (ITGAV&ITGB3) Heterodimer, His, Cynomolgus at 0.5μg/ml (100μl/Well) on the plate can bind Anti­alpha V beta 3 Antibody, hFc Tag. Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 112.31 kDa (ITGAV) & 81.27 kDa (ITGB3)
Apparent Molecular Weight Due to glycosylation, the protein migrates 95-140 to kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.
返回

技术背景
Target Background ITGAV&ITGB3 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling. ITGAV&ITGB3 binds to FGF1 and this binding is essential for FGF1 signaling. ITGAV&ITGB3 binds to FGF2 and this binding is essential for FGF2 signaling. ITGAV&ITGB3 binds to IGF1 and this binding is essential for IGF1 signaling. ITGAV&ITGB3 binds to IGF2 and this binding is essential for IGF2 signaling.
Synonyms αVβ3; Integrin alpha V beta 3; beta3; alphaV; ITGAV&ITGB3;Integrin alpha V β 3; β3
返回

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.