目录产品 » Mature TGF beta 1[Biotin], Avi, Human
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Mature TGF beta 1[Biotin], Avi, Human

TGF-beta 1 (transforming growth factor beta 1) is one of three closely related mammalian members of the large TGF-beta superfamily that share a characteristic cystine knot structure. TGF-beta 1, -2 and -3 are highly pleiotropic cytokines that are proposed to act as cellular switches that regulate processes such as immune function, proliferation and epithelial-mesenchymal transition.Transforming growth factor beta-1 is multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration.
￥6600
Z04552-100

产品简介
Species Human
Protein Construction
Mature TGF beta 1 (Ala279-Ser390)
Accession # P01137		 Avi
N-term C-term
Conjugate Biotin
Purity > 95% as determined by Bis-Tris PAGE
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Immobilized Human TGF­beta RII, hFc Tag at 1μg/ml (100μl/well) on the plate can bind Mature TGF beta 1[Biotin], Avi, Human. Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 13.2 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 15-18 kDa under reduced (R) condition and 26-30 kDa under Non reducing (N) condition based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in 50mM Glycine, 150mM NaCl (pH 2.5).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in 4mM HCl.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.
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图例
Mature TGF Beta 1[Biotin], Avi, Human

Immobilized Human TGF-beta RII, hFc Tag at 1 μg/ml (100 μl/well) on the plate. Dose response curve for Mature TGF beta 1[Biotin], Avi, Human, Avi Tag with the EC50 of 12.4 ng/ml determined by ELISA. »

Mature TGF Beta 1[Biotin], Avi, Human

Mature TGF beta 1[Biotin], Avi, Human on Bis-Tris PAGE under reduced (R) condition and Non reducing (N) condition. The purity is greater than 95%. »

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技术背景
Target Background TGF-beta 1 (transforming growth factor beta 1) is one of three closely related mammalian members of the large TGF-beta superfamily that share a characteristic cystine knot structure. TGF-beta 1, -2 and -3 are highly pleiotropic cytokines that are proposed to act as cellular switches that regulate processes such as immune function, proliferation and epithelial-mesenchymal transition.Transforming growth factor beta-1 is multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration.
Synonyms CEDLAP; DPD1; TGF beta1; TGFB; TGFB1; TGFbeta; TGF-beta-1; TGF β1; TGFβ; TGF-β-1
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For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.