目录产品 » GDF15 hFc Chimera[Biotin], Human
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GDF15 hFc Chimera[Biotin], Human

Growth and differentiation factor 15 (GDF15) is an inflammation-associated hormone with poorly defined biology. Here, we investigated the role of GDF15 in bacterial and viral infections. Inflammation induced GDF15, and that GDF15 was necessary for surviving both bacterial and viral infections, as well as sepsis. The protective effects of GDF15 were largely independent of pathogen control or the magnitude of inflammatory response, suggesting a role in disease tolerance.
￥7400
Z04470-100

产品简介
Species Human
Protein Construction
hFc GDF15 (Ala197-Ile308)
Accession # Q99988
N-term C-term
Conjugate Biotin
Purity > 95% as determined by Bis­Tris PAGE 
> 95% as determined by HPLC
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Immobilized Human GFRAL, His Tag at 0.5μg/ml (100μl/Well) on the plate can bind GDF15 hFc Chimera[Biotin], Human. Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 37.9 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 40-50 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.
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图例
GDF15 HFc Chimera[Biotin], Human

Immobilized Human GFRAL, His Tag at 0.5 μg/ml (100 μl/well) on the plate. Dose response curve for GDF15 hFc Chimera[Biotin], Human, hFc Tag with the EC50 of 7.0 ng/ml determined by ELISA. »

GDF15 HFc Chimera[Biotin], Human

The purity of GDF15 hFc Chimera[Biotin], Human is greater than 95% as determined by SEC-HPLC. »

GDF15 HFc Chimera[Biotin], Human

GDF15 hFc Chimera[Biotin], Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. »

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技术背景
Target Background Growth and differentiation factor 15 (GDF15) is an inflammation-associated hormone with poorly defined biology. Here, we investigated the role of GDF15 in bacterial and viral infections. Inflammation induced GDF15, and that GDF15 was necessary for surviving both bacterial and viral infections, as well as sepsis. The protective effects of GDF15 were largely independent of pathogen control or the magnitude of inflammatory response, suggesting a role in disease tolerance.
Synonyms GDF-15; MIC-1; NAG-1; PDF; PLAB; PTGFB; GDF15; MIC1; RG-1; Placental TGF-beta; PTGF-beta; PTGFBPTGF-beta; Placental TGF-β; PTGF-β; PTGFBPTGF-β
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For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.