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FGF10[Biotin], Human

Fibroblast growth factor 10 (FGF10) regulates multiple stages of structural lung morphogenesis, cellular differentiation, and the response to injury. As a driver of lung airway branching morphogenesis, FGF10 signaling defects during development lead to neonatal lung disease. Lung diseases impact patients across the lifespan, from infants in the first minutes of life through the aged population. Congenital abnormalities of lung structure can cause lung disease at birth or make adults more susceptible to chronic disease.
￥5800
Z04457-100

产品简介
Species Human
Protein Construction
FGF10 (Gln38-Ser208)
Accession # O15520
Conjugate Biotin
Purity > 95% as determined by Bis­Tris PAGE
> 95% as determined by HPLC
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity FGF10[Biotin], Human immobilized on CM5 Chip can bind Human FGFR2 alpha IIIb, His tag in SPR assay (Biacore T200). Test result was comparable to standard batch.
Expression System E.coli
Theoretical Molecular Weight 19.3 kDa
Apparent Molecular Weight The protein has a predicted MW of 19.3 kDa same as Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in 20mM Tris,150mM NaCl (pH 8.0).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.
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图例
FGF10[Biotin], Human

The purity of FGF10[Biotin], Human is greater than 95% as determined by SEC-HPLC. »

FGF10[Biotin], Human

FGF10[Biotin], Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. »

FGF10[Biotin], Human

FGF10[Biotin], Human, No tag immobilized on CM5 Chip can bind Human FGFR2 alpha IIIb, His tag with an affinity constant of 147.70 nM as determined in SPR assay (Biacore T200) (QC Test). »

FGF10[Biotin], Human

Serial dilutions of Anti-FGFR2 alpha IIIb Antibody were added into Human FGFR2 alpha IIIb, His Tag : FGF10[Biotin], Human, No Tag binding reactioins. The half maximal inhibitiory concentration(IC50) is 0.6ng/ml. »

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技术背景
Target Background Fibroblast growth factor 10 (FGF10) regulates multiple stages of structural lung morphogenesis, cellular differentiation, and the response to injury. As a driver of lung airway branching morphogenesis, FGF10 signaling defects during development lead to neonatal lung disease. Lung diseases impact patients across the lifespan, from infants in the first minutes of life through the aged population. Congenital abnormalities of lung structure can cause lung disease at birth or make adults more susceptible to chronic disease.
Synonyms FGF-10; KGF2
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For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.