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Maspin, Human

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Mammary serine protease inhibitor (Maspin), also known as serpin B5 is a non-inhibitory serpin that is encoded by the SERPINB5 gene in humans. The protein is expressed predominantly in normal mammary epithelial cells but at significantly reduced levels or absent in most breast carcinomas. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity. The maspin functions as tumor suppressor, blocking the growth, invasion, and metastatic properties of mammary tumors. This anti-tumor activity is achieved, in part, by the ability of maspin to inhibit angiogenesis and to preferentially promote apoptosis of tumor cells.
Z03583
Description

Mammary serine protease inhibitor (Maspin), also known as serpin B5 is a non-inhibitory serpin that is encoded by the SERPINB5 gene in humans. The protein is expressed predominantly in normal mammary epithelial cells but at significantly reduced levels or absent in most breast carcinomas. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity. The maspin functions as tumor suppressor, blocking the growth, invasion, and metastatic properties of mammary tumors. This anti-tumor activity is achieved, in part, by the ability of maspin to inhibit angiogenesis and to preferentially promote apoptosis of tumor cells.
Synonyms

Serpin B5; Protease Inhibitor 5

Note

For laboratory research use only. Direct human use, including taking orally and injection and clinical use are forbidden.

产品简介
Source E.coli
Species Human
序列
Accession# P36952-2 ( Met1-Ser231)
Purity > 90% as determined by reducing SDS-PAGE.
Endotoxin Level < 0.1 ng/µg (1 EU/µg) as determined by LAL test.
Molecular Weight ~29 kDa, on SDS-PAGE under reducing conditions.
Reconstitution Reconstitute the lyophilized protein in distilled water up to 100 μg/mL.
Formulation Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
Storage & Stability This product can be stored at -20°C or below for 12 months. Reconstituted protein solution can be stored at 4-7°C for 2-7 days. Please avoid repeated freeze-thaw cycles.
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