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β-Amyloid (1-42), human

This peptide is well suited to the quantitative determination of A 42 peptide. Alzheimer’s disease (AD) is characterized by the presence of extracellular plaques and intracellular neurofibrillary tangles (NFTs) in the brain. The major protein component of these plaques is beta amyloid peptide (A), a 40- to 43- amino-acid peptide cleaved from amyloid precursor protein by secretase (BACE) and a putative (gamma) secretase. Increased release of the ‘longer forms’ of A peptide, A 42 and A 43, which have a greater tendency to aggregate than A 40, occurs in individuals expressing certain genetic mutations, expressing certain ApoE alleles or may other, still undiscovered factors.
￥1100
RP10017

产品概述
Description This peptide is well suited to the quantitative determination of A 42 peptide. Alzheimer’s disease (AD) is characterized by the presence of extracellular plaques and intracellular neurofibrillary tangles (NFTs) in the brain. The major protein component of these plaques is beta amyloid peptide (A), a 40- to 43- amino-acid peptide cleaved from amyloid precursor protein by secretase (BACE) and a putative (gamma) secretase. Increased release of the ‘longer forms’ of A peptide, A 42 and A 43, which have a greater tendency to aggregate than A 40, occurs in individuals expressing certain genetic mutations, expressing certain ApoE alleles or may other, still undiscovered factors.
Cas No 107761-42-2
Sequence
{ASP}{ALA}{GLU}{PHE}{ARG}{HIS}{ASP}{SER}{GLY}{TYR}{GLU}{VAL}
{HIS}{HIS}{GLN}{LYS}{LEU}{VAL}{PHE}{PHE}{ALA}{GLU}{ASP}{VAL}
{GLY}{SER}{ASN}{LYS}{GLY}{ALA}{ILE}{ILE}{GLY}{LEU}{MET}{VAL}
{GLY}{GLY}{VAL}{VAL}{ILE}{ALA}
Sequence Shortening DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA
Molecular Formula C203H311N55O60S1
Molecular Weight 4514.1
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产品属性
Purity > 95%
Solubility Soluble in Ultrapure water under 1mg/ml
Form Lyophilized
Storage Store at -20°C
Note This product is a chemically-modified β-amyloid (1-42) precursor, which belongs to GenScript’s click peptides. The click peptides; are best described by the following key features:
1. Enhanced Stability—The O-acyl moiety within the click peptide is stable even under acidic pH.
2. Convenient and quick process—The click peptides can be easily converted to native peptide at pH 7.4 or above.
3. No by-product formation in the conversion process.
4. Superior quality—After the click, the aggregative property of the peptides is significantly minimized compared to its native format.
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图例
β-Amyloid (1-42), Human

β-amyloid (1-42) click peptide »

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相关文献
Jawad Ali, et al. Neuroprotective Effects of N-methyl-(2S, 4R)-trans-4-hydroxy-L-proline (NMP) against Amyloid-β-Induced Alzheimer's Disease Mouse Model. Nutrients. (2023-12)
Sudipta Panja, et al. FAD-Deficient P187S mutation of NAD(P)H:quinone oxidoreductase 1 (NQO1*2) binds and accelerates β-amyloid aggregation. Biosci Rep. (2022-10)
Xinyu Li, et al. Ratiometric Imaging of Mitochondrial Hydrogen Peroxide in Aβ-Mediated Neurotoxicity. ACS Sens. (2022-02)
Jatin Machhi, et al. CD4+ effector T cells accelerate Alzheimer's disease in mice. J Neuroinflammation. (2021-11)
Roberts KF, et al. Cobalt(III) Schiff base complexes stabilize non-fibrillar amyloid-β aggregates with reduced toxicity. Journal of inorganic biochemistry. (2020-12)
Wang Z, et al. Furosemide as a Probe Molecule for the Treatment of Neuroinflammation in Alzheimer's Disease. ACS Chemical Neuroscience. (2020-12)
Roberta Ruotolo Ilaria Minato Pietro La Vitola Luisa Artioli Claudio Curti Valentina Franceschi Nicoletta Brindani Davide Amidani Laura Colombo Mario Salmona Gianluigi Forloni Gaetano Donofrio Claudia Balducci Daniele Del Rio Simone Ottonello, et al. Flavonoid‐Derived Human Phenyl‐γ‐Valerolactone Metabolites Selectively Detoxify Amyloid‐β Oligomers and Prevent Memory Impairment in a Mouse Model of …. Molecular Nutrition & Food Research. (2020-01)
Ruotolo R, et al. Flavonoid-Derived Human Phenyl-γ-Valerolactone Metabolites Selectively Detoxify Amyloid-β Oligomers and Prevent Memory Impairment in a Mouse Model of Alzheimer's Disease. Mol Nutr Food Res. (2020)
Cotrina EY, et al. Calorimetric Studies of Binary and Ternary Molecular Interactions between Transthyretin, Aβ Peptides, and Small-Molecule Chaperones toward an Alternative Strategy for Alzheimer's Disease Drug Discovery. J Med Chem. (2020)
Yan Wang, et al. Dicer1 is reduced in APPswe/PSEN1dE9 mice and is regulated by Nrf2. biorxiv. (2019)
MdShadab, et al. In vitro neuroprotective effects of naringenin nanoemulsion against β-amyloid toxicity through the regulation of amyloidogenesis and tau phosphorylation. Int. J. Biol. Macromol. (2018-10)
Mantile F, et al. Alum and Squalene-Oil-in-Water Emulsion Enhance the Titer and Avidity of Anti-Aβ Antibodies Induced by Multimeric Protein Antigen (1-11)E2, Preserving the Igg1-Skewed Isotype Distribution. PLoS One. (2014-07)
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