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GAD65+GAD67 Antibody, pAb, Rabbit

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Glutamic Acid Decarboxylase (GAD) catalyzes the conversion of glutamate to gamma-aminobutyric acid (GABA), the principal inhibitory neurotransmitter in the brain. There are two isoforms of GAD, GAD65 (GAD2) and GAD67 (GAD1) (65 and 67 kDa, respectively) encoded by two different genes. The two isoforms have distinct intraneuronal distribution in the brain. There is 64% amino acid identity between the two isoforms. The highest degree of diversity appears to be located at the N-terminus, which in GAD65 is required for targeting the enzyme to GABA-containing secretory vesicles. GAD65 is primarily found in nerve terminals. GAD67 has been thought to be primarily located in the nerve cell body and has been identified as a major autoantigen in type 1 diabetes.GenScript Rabbit Anti-GAD65+GAD67 Polyclonal Antibody is developed in rabbit using a KLH-coupled synthetic peptide within residues 550-600 of human GAD65 (Swiss Prot: Q05329) and GAD67 (Swiss Prot: Q99259).
A01437
产品概述
Specificity GenScript Rabbit Anti-GAD65+GAD67 Polyclonal Antibody detects endogenous levels of mouse and rat GAD65 and GAD67 protein. This antibody reacts specifically with GAD65 and GAD67 isoforms. It is predicted to react with human GAD65 and GAD67 according to sequence homology.
Positive Control: Mouse brain and rat brain
Host Species Rabbit
Immunogen KLH-coupled synthetic peptide within residues 550-600 of human GAD65 (Swiss Prot: Q05329) and GAD67 (Swiss Prot: Q99259).
Species Reactivity Mouse and rat. This product has not been tested for other species yet.
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产品属性
Concentration 0.5 mg/ml, lyophilized with PBS, pH 7.4, containing 0.02% sodium azide
Reconstitution Reconstitute the lyophilized powder with deionized water (or equivalent) to antibody concentration of 0.5 mg/ml.
Purification Immunoaffinity chromatography
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技术背景
Target Background Glutamic Acid Decarboxylase (GAD) catalyzes the conversion of glutamate to gamma-aminobutyric acid (GABA), the principal inhibitory neurotransmitter in the brain. There are two isoforms of GAD, GAD65 (GAD2) and GAD67 (GAD1) (65 and 67 kDa, respectively) encoded by two different genes. The two isoforms have distinct intraneuronal distribution in the brain. There is 64% amino acid identity between the two isoforms. The highest degree of diversity appears to be located at the N-terminus, which in GAD65 is required for targeting the enzyme to GABA-containing secretory vesicles. GAD65 is primarily found in nerve terminals. GAD67 has been thought to be primarily located in the nerve cell body and has been identified as a major autoantigen in type 1 diabetes.

GenScript Rabbit Anti-GAD65+GAD67 Polyclonal Antibody is developed in rabbit using a KLH-coupled synthetic peptide within residues 550-600 of human GAD65 (Swiss Prot: Q05329) and GAD67 (Swiss Prot: Q99259).
Synonyms Rabbit Anti-GAD1/2 antibody;
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相关文献
Shila Shahbazian, et al. Polysialic acid in the rat brainstem and thoracolumbar spinal cord: Distribution, cellular location, and comparison with mouse. J Comp Neurol. (2020)