目录产品 » Integrin alpha 2 beta 1 (ITGA2&ITGB1) Heterodimer, His, Mouse
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Integrin alpha 2 beta 1 (ITGA2&ITGB1) Heterodimer, His, Mouse

Integrin alpha 2 beta 1 is a positive regulator of collagenase (MMP-1) and collagen alpha 1(I) gene expression.HOS cells normally lacking alpha 2 beta 1 integrin were forced to express it, and this prevented the down-regulation in the levels of alpha 1 (I) collagen mRNA when cells were grown inside collagen gels. The data indicate that the level of MMP-1 expression is regulated by the collagen receptor alpha 2 beta 1 integrin.
￥4100
Z06221

产品简介
Species Mouse
Protein Construction
Integrin alpha 2 beta 1 (ITGA2&ITGB1) Heterodimer[Tyr27-Thr1129(ITGA2) acidic tail & Gln21-Asp728(ITGB1) basic tail]
Accession # Q62469(ITGA2)&P09055-1(ITGB1)		 His
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
> 95% as determined by HPLC
Endotoxin Level Less than 1EU per μg by the LAL method.
Expression System HEK293
Theoretical Molecular Weight 126.60 kDa(ITGA2)&82.80 kDa(ITGB1)
Apparent Molecular Weight Due to glycosylation, the protein migrates to 128-138 kDa(ITGA2)&105-115 kDa(ITGB1) based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.
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图例
Integrin Alpha 2 Beta 1 (ITGA2&ITGB1) Heterodimer, His, Mouse

The purity of Integrin alpha 2 beta 1 (ITGA2&ITGB1) Heterodimer, His, Mouse is greater than 95% as determined by SEC-HPLC. »

Integrin Alpha 2 Beta 1 (ITGA2&ITGB1) Heterodimer, His, Mouse

Integrin alpha 2 beta 1 (ITGA2&ITGB1) Heterodimer, His, Mouse on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. »

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技术背景
Target Background Integrin alpha 2 beta 1 is a positive regulator of collagenase (MMP-1) and collagen alpha 1(I) gene expression.HOS cells normally lacking alpha 2 beta 1 integrin were forced to express it, and this prevented the down-regulation in the levels of alpha 1 (I) collagen mRNA when cells were grown inside collagen gels. The data indicate that the level of MMP-1 expression is regulated by the collagen receptor alpha 2 beta 1 integrin.
Synonyms α2β1; ITGA2&ITGB1; ITGA2; ITGB1;
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For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.