| ￥4100 | |
| Z05533 | |
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| Species | Human | ||||||
| Protein Construction |
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| Purity |
> 95% as determined by Bis-Tris PAGE > 95% as determined by HPLC |
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| Endotoxin Level | Less than 1 EU per μg by the LAL method. | ||||||
| Biological Activity | Measured by its binding ability in a functional ELISA. Immobilized Integrin alpha V beta 8 (ITGAV&ITGB8) Heterodimer, His & Avi, Human at 5 μg/ml (100μl/well) on the plate can bind Biotinylated Human Latent TGF beta 1, His Tag. Test result was comparable to standard batch. | ||||||
| Expression System | HEK293 | ||||||
| Theoretical Molecular Weight | 114 kDa (ITGAV) and 76 kDa (ITGB8) | ||||||
| Apparent Molecular Weight | Due to glycosylation, the protein migrates to 90-150 kDa based on Bis-Tris PAGE result. | ||||||
| Formulation | Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4). | ||||||
| Reconstitution | Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water. | ||||||
| Storage & Stability | Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles. |
| Target Background | Integrin αVβ8 is a heterodimeric cell surface receptor involved in various cellular processes, including cell adhesion, migration, and signaling. It is recognized for its unique role in activating TGF-β and has been implicated in immune responses and tissue homeostasis. Due to its distinctive structure and function, integrin αVβ8 is considered atypical among integrin family members. |
| Synonyms | αVβ8; Integrin alpha V beta 8; TGAV&ITGB8;Integrin alpha V β 8 |
For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.
