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CTCF antibody, pAb, Rabbit

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CTCF (CCCTC-binding factor) is a highly conserved zinc finger protein which plays an important role in transcriptional activation/repression, insulation, imprinting, and X chromosome inactivation depending on the DNA context of the binding site. It contains a DNA-binding domain composed of 11 zinc-fingers and the DNA target sequences recognized by CTCF which are fairly long and strikingly diverse. CTCF can be phosphorylated by the protein kinase CK2, as well as poly(ADP-ribosyl)ated. The latter modification regulates its activity as a chromatin insulator. GenScript CTCF Antibody is developed in rabbit using a KLH-coupled synthetic peptide within residues 150–200 of human CTCF (Swiss Prot: P49711).
A01529
产品概述
Specificity GenScript CTCF Antibody detects endogenous levels of human CTCF. Predicted to react with rat CTCF according to sequence homology.
Positive Control: Ramos, K562 and A431
Host Species Rabbit
Immunogen KLH-coupled synthetic peptide within residues 150-200 of human CTCF (Swiss Prot: P49711).
Species Reactivity Human
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产品属性
Concentration 0.5 mg/ml, lyophilized with PBS, pH 7.4, containing 0.02% sodium azide
Reconstitution Reconstitute the lyophilized powder with deionized water (or equivalent) to an antibody concentration of 0.5 mg/ml.
Purification Immunoaffinity chromatography
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技术背景
Target Background CTCF (CCCTC-binding factor) is a highly conserved zinc finger protein which plays an important role in transcriptional activation/repression, insulation, imprinting, and X chromosome inactivation depending on the DNA context of the binding site. It contains a DNA-binding domain composed of 11 zinc-fingers and the DNA target sequences recognized by CTCF which are fairly long and strikingly diverse. CTCF can be phosphorylated by the protein kinase CK2, as well as poly(ADP-ribosyl)ated. The latter modification regulates its activity as a chromatin insulator. GenScript CTCF Antibody is developed in rabbit using a KLH-coupled synthetic peptide within residues 150–200 of human CTCF (Swiss Prot: P49711).
Synonyms 11 zinc finger protein antibody;
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