• 抗原物种:
  SARS-CoV-2
• 表达系统:
  CHO
• 蛋白结构:

  Spike RBD [Arg319-Ser591 (L452R, T478K)] Accession # P0DTC2	Avi	Poly-His
  N-term		C-term

• 偶物联:
  HRP
• 图片:
  

  [1 Image]

• 抗原物种:
  S. pyogenes
• 表达系统:
  Recombinant Cas9-based fusion with double-ended NLS expressed by E.coli
• 描述
  PE2 is a revolutionary genome editing technology that allows for precise genetic modifications with minimal unintended effects. It integrates a Cas9-nickase fusion protein with a reverse transcriptase and a prime-editing guide RNA (pegRNA), enabling flexible editing capabilities.PE 2 represents a cutting-edge development in genome editing technology, offering significant advantages over traditional methods in terms of accuracy and versatility.​

• 抗原物种:
  S. pyogenes
• 表达系统:
  Recombinant Cas9-based fusion with three NLS expressed by E.coli
• 描述
  PE7 is a fusion protein of the small RNA-binding protein La to the prime editor. Research indicates that PE7 has demonstrated substantial improvements in intended editing efficiencies across various cell lines and genomic loci compared to previous versions like PEmax. This development holds promise for a wide range of applications in both basic research and therapeutic settings.

• 抗原物种:
  S. pyogenes
• 表达系统:
  Recombinant Cas9-based fusion with three NLS expressed by E.coli
• 描述
  PE6C focuses on enhancing the performance of prime editing in transgenic rice plants. This specific variant of the prime editing technology is tailored to address the challenges of genetic improvement in crops, contributing to enhanced editing precision and efficiency in agricultural applications. The effectiveness of PE6c stems from its design improvements that enable it to facilitate targeted insertions and modifications in plant genomes.

• 抗原物种:
  S. pyogenes
• 表达系统:
  Recombinant Cas9-based fusion with three NLS expressed by E.coli
• 描述
  PE6d is designed to optimize the efficiency of prime editing by altering certain components of the prime editor framework. It incorporates elements that minimize the chances of errors and maximize successful genomic edits across various cell types. This improvement results in enhanced editing accuracy and reduced byproducts, such as unintended indels.

• 抗原物种:
  S. pyogenes
• 表达系统:
  Recombinant Cas9-based fusion with three NLS expressed by E.coli
• 描述
  PEmax is an improved version of PE2 with additional NLS and improved nCas9 domain, facilitating precise genome editing without the need for double-stranded DNA breaks. It significantly increases editing efficiency and accuracy compared to earlier systems and allows for a broader range of base conversions and edits within the genome design

• 抗原物种:
  S. pyogenes
• 表达系统:
  Recombinant Cas9-based fusion with three NLS expressed by E.coli
• 描述
  PE6b is a variant of the prime editor protein specifically designed for genome editing in living cells. It enhances the efficiency of genome edits compared to earlier versions of prime editors. Notably, editors like PE6b are smaller in size, allowing for more efficient delivery when used in medical and therapeutic applications.

1 Citations

• 抗原物种:
  Bovine
• 描述
  Enterokinase (EK) is an enzyme produced by cells of the duodenum and involved in human digestion. It plays a role of turning trypsinogen to its active form trypsin, and indirectly activates the pancreatic digestive enzymes. Enterokinase is a specific protease that cleaves after a lysine preceded by four aspartic acids: Asp-Asp-Asp-Asp-Lys. Enterokinase will not work if the recognition site is followed by a proline. rbEK with 6 × His-tag binds with Ni2+ affinity chromatography and was designed for removing from digestion system.
• 图片:
  

  [5 Images]

• 抗原物种:
  Acidaminococcus sp. (strain BV3L6)
• 浓度
  4(±10%) mg/ml
• 描述
  The clustered regularly interspaced short palindromic repeats, known as CRISPR systems are adaptive immune mechanisms commonly present in archaea and bacteria. The CRISPR systems enable the host to specifically target and cleave foreign nucleic acids thus targeting infectiousviruses and plasmids. Recently, a type V CRISPR system has been identified in several bacteria, the Cpf1 CRISPR from Prevotella and Francisella 1. In contrast to Cas9 systems, CRISPR/Cpf1 systems are smaller in size, do not require an additional trans-activating crRNA (tracrRNA), and allow for targeting of additional genomic regions by cleaveing the target DNA proceeded by a short T-rich protospacer-adjacent motif (PAM). On the other hand, the Cas9 system requires a G-rich PAM following the target DNA. Furthermore, Cas12a/Cpf1 introduces a staggered DNA double stranded break with a 4 or 5-nt 5’ overhang. Recombinant Acidaminococcus sp. BV3L6 Cas12a (cpf1) nuclease is expressed in E. coli and purified. The nuclease contains nuclear localization sequence (NLS) at the C-terminus and 6× His-tag at the C-terminus.
• 图片:
  

  [1 Image]

8 Citations

• 抗原物种:
  SARS-CoV-2
• 表达系统:
  Sf9 insect cells
• 蛋白结构:

  Spike ECD (Val16-Pro1213) Accession # P0DTC2	Poly-His	Flag
  N-term		C-term

• 同义词:
  S protein; S-ECD; ECD protein; ECD; 2019-nCoV ECD
• 图片:
  

  [6 Images]