SARS-CoV-2 Spike protein (RBD, E484Q, L452R, Avi & His Tag)-HRP

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SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) also known as 2019-nCoV (2019 Novel Coronavirus) is a virus that causes illnesses ranging from the common cold to severe diseases. Lineage B.1.617, also known as G/452.V3, was first identified in October 2020 in India. This variant has the double mutations E484Q and L452R in the spike proteins. Emerging research suggests the variant may be more transmissible than previously evolved ones. Whether the effectiveness of currently-deployed vaccines is affected remains under investigation. Moreover, the sublineage B.1.617.2 has been redesignated as "variant of concern" (VOC-21APR-02) in May 2021, which spreads more quickly than the original version of the virus.

产品编号	Z03608
规格	定制报价

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产品简介

Species

SARS-CoV-2

Protein Construction

Spike RBD [Arg319-Ser591 (E484Q, L452R)] Accession # P0DTC2	Avi	Poly-His
N-term		C-term

Conjugate

HRP

Biological Activity

This protein is validated to bind with human ACE2 (Cat. No. Z03516) in functional ELISA assay.

Expression System

CHO

Application

The optimal dilution ratio should be determined by the end user for specific applications.
ELISA 1:1000

Formulation

Supplied as a solution in PBS, pH 7.4, 0.1% ProClin 300.

Storage & Stability

Upon receiving, this product remains stable for up to 3 months at 2-8°C. Protect from light.

技术背景

Target Background	SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) also known as 2019-nCoV (2019 Novel Coronavirus) is a virus that causes illnesses ranging from the common cold to severe diseases. Lineage B.1.617, also known as G/452.V3, was first identified in October 2020 in India. This variant has the double mutations E484Q and L452R in the spike proteins. Emerging research suggests the variant may be more transmissible than previously evolved ones. Whether the effectiveness of currently-deployed vaccines is affected remains under investigation. Moreover, the sublineage B.1.617.2 has been redesignated as "variant of concern" (VOC-21APR-02) in May 2021, which spreads more quickly than the original version of the virus.
Synonyms	Lineage B.1.617; “double mutation" variant; India variant
References	1. COVID-19 Weekly Epidemiological Update. 2. Transmission, infectivity, and neutralization of a spike L452R SARS-CoV-2 variant. 3. SARS-CoV-2 variants of concern and variants under investigation in England.