SARS-CoV-2 Spike protein (S1, Q52R, del 69-70, E484K, Q677H, D614G, His Tag)

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SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) also known as 2019-nCoV (2019 Novel Coronavirus) is a virus that causes illnesses ranging from the common cold to severe diseases. The new variant B.1.525 was first detected by genome sequence in mid-December in Nigeria but was also quickly found in cases in the United Kingdom, France, and elsewhere. The mutation of B.1.525 may increase transmissibility, virulence, and immune escape, the amino acid substitutions Q52R, E484K, Q677H, D614G are located in the spike protein with the deletions at positions 69-70.

产品编号	Z03604
规格	定制报价

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产品简介

Species

SARS-CoV-2

Protein Construction

Expressed with the mutations of Q52R, del 69-70, E484K, Q677H, D614G.

S1 protein (Gln14-Arg685) Accession # P0DTC2	Poly-His
N-term	C-term

Purity

> 90% as analyzed by SDS-PAGE

Endotoxin Level

< 0.2 EU/μg of protein by gel clotting method

Biological Activity

This protein is validated to bind with human ACE2 in functional ELISA assay.

Expression System

CHO

Theoretical Molecular Weight

75.7 kDa

Formulation

Supplied as a solution in PBS, pH 7.4.

Concentration

Please refer to the COA for the specific lot.

Storage & Stability

Upon receiving, this product remains stable for up to 6 months at -20°C or below. Please avoid repeated freeze-thaw cycles.

技术背景

Target Background	SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) also known as 2019-nCoV (2019 Novel Coronavirus) is a virus that causes illnesses ranging from the common cold to severe diseases. The new variant B.1.525 was first detected by genome sequence in mid-December in Nigeria but was also quickly found in cases in the United Kingdom, France, and elsewhere. The mutation of B.1.525 may increase transmissibility, virulence, and immune escape, the amino acid substitutions Q52R, E484K, Q677H, D614G are located in the spike protein with the deletions at positions 69-70.
Synonyms	B.1.525; VUI-21FEB-03; VUI-202102/03; UK1188; Nigerian variant NB.1.525; Eta variant
References	1. A New Covid-19 Variant From Nigeria Raises Increased Concerns For Containment And Vaccination. 2. Variants of concern or under investigation: data up to 21 April 2021. 3. B.1.525.